Melania focused on her “Be Best” campaign, which aimed to address the well-being of youth, advocating against cyberbullying and drug use. Her public persona was marked by a sense of privacy and a keen interest in fashion.

Jill Biden is known for her advocacy in education, military families, and cancer research. She is a lifelong educator and the first First Lady to continue her career while in office, teaching at a community college. Her initiative, Joining Forces, co-founded with Michelle Obama, supports military families.

Michelle Obama was widely recognized for her “Let’s Move!” initiative to combat childhood obesity, which included efforts to improve school lunches and promote physical activity. She also launched the “Reach Higher” initiative to encourage continued education beyond high school.

Laura Bush, a former librarian, was known for her commitment to education and literacy, launching the National Book Festival. She also focused on women’s health issues and human rights, particularly in Afghanistan.

Hillary Clinton played a prominent role in policy initiatives, particularly in health care. She led the Task Force on National Health Care Reform. Her involvement in policy was more pronounced than many of her predecessors.

Barbara Bush promoted literacy as her primary cause, founding the Barbara Bush Foundation for Family Literacy. She was known for her down-to-earth, grandmotherly public persona.

Nancy Reagan was noted for her “Just Say No” campaign, aimed at discouraging children and teenagers from engaging in recreational drug use. She was also known for her strong influence over President Ronald Reagan, particularly in his second term.

Rosalynn Carter was an active advocate for mental health, working to improve the lives of those with mental illnesses and lobbying for legislation to provide better care. She also served as an unofficial envoy abroad.

Betty Ford was open about her struggles with breast cancer and substance abuse, bringing attention to both issues. She was a staunch advocate for the Equal Rights Amendment and women’s rights.